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Cancer Vaccines

Old 01-10-2019, 06:54 PM
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Default Cancer Vaccines

My daughter, who works for a biomedical company in California, has told me they are beginning their first human trials for cancer vaccines (Jan 3rd) that are designed specifically, for each individual. As far as I know, the individuals involved are those whose cancer is considered inoperable or reversible. Recently ... reduced regulations are giving some a last chance.

Interesting stuff.
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Old 01-11-2019, 01:10 PM
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Originally Posted by DavenFla View Post
My daughter, who works for a biomedical company in California, has told me they are beginning their first human trials for cancer vaccines (Jan 3rd) that are designed specifically, for each individual. As far as I know, the individuals involved are those whose cancer is considered inoperable or reversible. Recently ... reduced regulations are giving some a last chance.

Interesting stuff.

Not to lessen her work, but if the trial patients already have cancer, then how is the drug a vaccine?
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Old 01-11-2019, 04:55 PM
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Originally Posted by Shore Native View Post
Not to lessen her work, but if the trial patients already have cancer, then how is the drug a vaccine?
You can get vaccines for stuff that has takin hold. These are promising, inert versions of the cancer that trick your white blood cells into overdrive to attack... It and the cancer cells.
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Old 01-11-2019, 05:08 PM
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My use of bio medical terms is out of ignorance... so I will stubble in my explanation, but I'll get more info from my daughter and be more specific. sorry about that... but I think as lay people, you get my drift.
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Old 01-11-2019, 05:09 PM
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Problem is there are over 250 types of cancer
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Old 01-11-2019, 05:11 PM
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Originally Posted by Re-Bait View Post
Problem is there are over 250 types of cancer
Bio specific for the individual. I'll know more soon...
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Old 01-11-2019, 05:28 PM
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Originally Posted by Re-Bait View Post
Problem is there are over 250 types of cancer
​​​​​​
Yup, and they pull out the cancer cells, make an inert version that supercharges your own immune system to go after it, and the cancer cells.

All our cells are splitting, growing and dying, and sometimes that goes wrong. Millions of times when things go wrong our bodies deal with it. Sometimes they can't or don't, so a vaccine might be a way to make your own body win the battle...
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Old 01-11-2019, 07:34 PM
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A friend of mine who is on the leading edge of transforming the delivery of medical services told me it won't be long before treatments and vaccines will be customized to the patient's DNA. It's one thing to treat a certain cancer, but it's another thing to take into account the patient's DNA.
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Old 01-16-2019, 08:35 AM
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Originally Posted by DavenFla View Post
My daughter, who works for a biomedical company in California, has told me they are beginning their first human trials for cancer vaccines (Jan 3rd) that are designed specifically, for each individual. As far as I know, the individuals involved are those whose cancer is considered inoperable or reversible. Recently ... reduced regulations are giving some a last chance.

Interesting stuff.
An article about this was just published in this weeks Nature journal. It is a long ways off but shows promise. The first trial was only 8 patients with glioblastoma... brain cancer. Two of the eight showed a response but none survived. New trials are in the works.
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Old 01-16-2019, 08:56 AM
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It’s called immunotherapy. Harvest your own cells, teach/program them to attack the cancer, reintroduce into your body and let them do their job.

Cutting edge stuff and being used for a lot more than just cancer. Lots and lots of trials going on all over the country.
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Old 01-16-2019, 09:04 AM
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I assume you are talking about Moderna? I don't like this stuff because it gives false hope. Ive heard lots of talk they will cure 50% of cancers in the next 50-75 years (so most of use will be dead). I worked for a company doing PRP research (stuff Peyton Manning put in his neck in Europe), lots of cancer companies in the building I worked in. You would see 100 millionaires at the end of their lift coming in for some last ditch effort to save them. Kidney cancer company right next door had no real results, but for 100k they would treat you. We would see 12-15 people some days going for help.
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Old 01-16-2019, 09:27 AM
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I worked for a company that has a marketed gene therapy product (CAR-T). It works, I personally know someone that has been cancer free for 10 years bc of gene therapy. There are going to multiple approvals of other gene therapy products in the next several years. These are going to cure most non-solid tumor cancers, e.g. lymphomas, myelomas, leukemias. There are some advances in solid tumors too, I am sure you have seen adds for the checkpoint inhibitor antibodies Ketruda and Opdivo.

The rub here is cost. The marketed gene therapy mentioned above has a price tag of 700K and it costs another 1M+ to administer it in a hospital setting. However it is a cure. Payers (insurance co's, medicare) will refuse to pay

Gene therapy is personalized medicine. They harness your T cells (immune system), use gene therapy to teach your immune cells to kill the cancer, grow the immune cells and then inject them back into you.
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Old 01-16-2019, 09:31 AM
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I welcome this, but will hold my breath and wait and see. For 40 years the experts have been telling us the cure for Muscular Dystrophy is right around the corner, and nothing has changed. I guess I am in the old school that big money and jobs intervene.
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Old 01-16-2019, 09:34 AM
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Originally Posted by WPBTH View Post
I assume you are talking about Moderna? I don't like this stuff because it gives false hope. Ive heard lots of talk they will cure 50% of cancers in the next 50-75 years (so most of use will be dead). I worked for a company doing PRP research (stuff Peyton Manning put in his neck in Europe), lots of cancer companies in the building I worked in. You would see 100 millionaires at the end of their lift coming in for some last ditch effort to save them. Kidney cancer company right next door had no real results, but for 100k they would treat you. We would see 12-15 people some days going for help.
Moderna is an mRNA platform company...it will be a really long time before and mRNA therapeutic makes it to market. However, there are other modalities that have recently been approved, check out Alnylam's product which is an siRNA.

This is not false hope and there is a ton of money going into this. Moderna broke a record when it IPO'd and there are rumors that the founders of Juno Therapeutics are starting another company that is going to raise 1B+ in a series A.
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Old 01-16-2019, 09:35 AM
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Originally Posted by DavenFla View Post
My daughter, who works for a biomedical company in California, has told me they are beginning their first human trials for cancer vaccines (Jan 3rd) that are designed specifically, for each individual. As far as I know, the individuals involved are those whose cancer is considered inoperable or reversible. Recently ... reduced regulations are giving some a last chance.

Interesting stuff.
I have a friend with the CDC who been doing a lot of work the last 4 years in cancer vaccines. As far as I know most of the research has been around dogs, Golden Retrievers in particular since they breed get more tumors and cancer than most other breeds
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Old 01-16-2019, 09:42 AM
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This sounds like one of the salesmen from the movie "Boiler Room" Where the broker would call an unsuspecting person and tell them we're in the final stages of clinical trials, which have gone great and I can get you in for only $5 per share. "What do you say let's pick up 1000 shares?"

Great movie if you haven't seen it BTW. Let's hope these vaccines work in the next 5 - 10 years for us old men on here!
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Old 01-16-2019, 05:21 PM
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This is an exciting time for the immunotherapies. I run a brain tumor foundation and we gave a lot of grants to researchers on vaccines over the years so I get to see whats up. This is for glioblastoma, which is basically incurable. There are many vaccines in clinical trial for brain tumors. Some reported about 20-25% 5 year survivals, compared to about 2% with the old treatments. The best part is most of these vaccines are simple shots in the arm with minimal side effects. 20% doesn't sound like much but I would pick 20% over 2% any time. .As they get approved and we can try them in combinations with immune enhancing drugs, we will see breakthroughs. Perhaps get that over 50% in a few years. Then the cure for most in a decade.
Most of these vaccines are personalized - either they make the vaccine from the patient's own tumor, or they pick the vaccine from a stock vaccine against targets identified in the patients' biopsy.
These are for treatment of existing tumors, not to prevent tumors. The vaccine triggers an immune response so your body fights it.
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