Good thing you asked, as you have
heard some bad information. Aluminum boat trailers, like steel boat trailers
"both" flex, and some flex a lot. To the best of my knowledge,
all aluminum trailers are bolted together with either galvanized or stainless steel hardware (at least those boat trailers manufactured in coastal areas), and there are literally tens of thousands of aluminum trailers in use around saltwater today. I have three, and I've been using aluminum boat trailers exclusively for the past 40 some years.
As for galvanic corrosion, unless you leave your aluminum trailer in the water for prolonged periods of time, your aluminum trailer will outlive you, so isolation of the aluminum and galvanized or stainless hardware is a non-issue.
As for
nuts and bolts vibrating loose - also a non-issue. If the trailer has galvanized hardware, the galvanizing on the bolt holds well to the galvanized coating on the nut. And similarly, if stainless bolts are used, most trailer manufacturers use
nylock nuts or lock washers - nylock nuts have nylon inserts inside of the nut that locks the nut onto the bolt. This is not to say that a wise trailer boater does not have to check his nuts now and then.