Alan,
I'm living in Jacksonville and have been over there a few times. It's a nice place to fish and there are a lot of grouper caught off the natural bottom over there. It's also a great place to fish inshore, but the bottom is hard so be careful you could lose a lower unit. The trout and redfish are the main targets but at time the big black drum show up too.
I would suggest you look on the Florida Sportsman fourm
http://outdoorsbest.zeroforum.com/zeroforum?id=13 in the Big Bend section. These guys can tell you what you need to know.
Fred